Methylation & Detox Genetic Test (Expanded Edition)
See how your DNA shapes methylation, detox, nutrition, and weight, and turn those insights into personalized guidance you can act on.
Genetic Tests are a one-time purchase
The Methylation & Detox Genetic Test (Expanded Edition) analyzes your DNA across 370+ insights, 92 traits, and seven areas: methylation and folate, detox capacity, nutrient processing, food response, energy, cardiovascular balance, and weight.
What your DNA reveals in this test
Methylation & folate
How well your body activates folate and B vitamins and keeps homocysteine in balance, the chemistry behind methylation. A practical starting point for the folate and B-vitamin choices you review with your provider.
Detoxification capacity
Your genetic capacity to process and clear everyday compounds, across both phases of detox and your antioxidant defenses. This reflects capacity, not exposure, and does not measure any substance in your body.
Nutrient processing
How your body absorbs and uses key vitamins and minerals like vitamin D, B12, iron, zinc, and selenium, so food and supplement choices can be personal instead of generic.
Diet & food response
How your genes may respond to eating styles like keto, Mediterranean, high-protein, and FODMAP, plus caffeine and how your gut interacts with food, to help you find what fits.
Energy & metabolism
How your genes may shape cellular energy and metabolism, including carnitine, CoQ10, creatine, and the adiponectin signal, relevant to everyday energy and recovery.
Cardiovascular balance
How your genes may relate to cholesterol, triglycerides, fatty acids, and sodium handling, useful context for the heart-healthy habits you discuss with your provider.
Weight & body composition
How your genes may relate to appetite, fat distribution, blood sugar response, and how your body tends to lose and regain weight, useful context for the weight and body-composition goals you discuss with your provider.
What this test covers
This test analyzes your DNA across the Methylation Pathway, Detoxification, Diet & Nutrition, and Weight & Body Fat reports: 372 markers across 92 traits, grouped into the seven areas below. For the detox area, results reflect genetic processing capacity, not your actual exposure, and do not measure any substance in your body.
Methylation & folate
The core methylation engine, from the folate and methionine cycles to the transsulfuration branch that feeds glutathione. The well-known MTHFR gene sits here, alongside COMT and CBS.
Detoxification capacity
How your genes may shape your body's natural ability to process and clear everyday compounds, across both phases of detox plus antioxidant defense. Important: this reflects genetic capacity, not your actual exposure, and does not measure any substance in your body.
Nutrient processing
How your body takes in and uses key vitamins and minerals, from folate and vitamin D to iron, zinc, and selenium. Your genes can shape how well you absorb or convert them.
Diet & food response
How your genes may respond to different eating styles, plus how your gut and everyday inputs like caffeine interact with food.
Energy & metabolism
How your body makes and uses cellular energy, covering carnitine, CoQ10, and creatine, plus the adiponectin signal that helps regulate metabolism.
Cardiovascular balance
How your genes may shape cholesterol, triglycerides, and fatty acids, plus the sodium and blood-pressure side of cardiovascular balance.
Weight & body composition
How your genes may influence body weight, fat distribution, appetite and eating behavior, blood sugar response, and how your body responds to losing weight and keeping it off. These reflect genetic predisposition, not certainty. The well-known weight genes FTO, MC4R, and PPARG sit here.
You do not have to act on all of it. Pick one or two areas, talk them over with your doctor or a dietitian, and build from there. This test is for wellness and education, not diagnosis.
From kit to results in four steps
Order your kit
We ship your DNA collection kit to your door for free, in discreet packaging.
Register and swab at home
Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.
Mail it back
Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.
Get your reports
In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.
Everything included with your test
Four genetic reports
Your Methylation Pathway, Detoxification, Diet & Nutrition, and Weight & Body Fat reports, delivered together in your PlexusDx Results Portal.
An at-home swab kit
The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.
Plain-English insights
Your results in clear language, with discussion points for you and your provider, not raw genetic data.
One swab, 372 markers
A single cheek swab covers all 372 markers across the four reports. Your DNA does not change, so you test once.
The reports inside this test
Each one is a full PlexusDx genetic report. Explore what they cover.
Methylation Pathway Genetic Report
How well your body runs the methylation cycle, from folate and B-vitamin activation to homocysteine balance, methyl donors, and neurotransmitter processing.
View reportDetoxification Genetic Report
Your genetic capacity to process and clear everyday compounds across both detox phases, plus antioxidant defense. This reflects capacity, not exposure.
View reportDiet and Nutrition Genetic Report
How your genes shape nutrient processing and food response, across vitamins, minerals, macronutrients, and eating styles like keto, Mediterranean, and FODMAP.
View reportWeight and Body Fat Genetic Report
How your genes relate to appetite, body weight, fat distribution, blood sugar response, and how your body responds to losing and regaining weight.
View reportAll your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.
PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.
One cheek swab unlocks 372 DNA insights across methylation, detox, nutrition, and weight.