Weight Management Protocols
Start your weight loss protocol now. Add genetic insight when it’s right for you.
Six prescription weight loss protocols — GLP-1 injectable, GLP-1 oral, microdose, and dual-compound options — prescribed by licensed providers in all 50 states. Every price is published before you enroll, every dose, every compound, every level. The optional Precision Peptide Genetic Test is available as a $99 add-on after your first month to refine your protocol around your biology, not someone else’s average.
Six protocols
From $129/mo
Up to $509/mo for premium dual-compound
Licensed care
Real prescribers
No chatbot, no AI rx
Availability
All 50 states
Telehealth, no clinic visit
Six protocols
From $129/mo
Up to $509/mo for premium dual-compound
Licensed care
Real prescribers
No chatbot, no AI rx
Availability
All 50 states
Telehealth, no clinic visit
- Six compounds — Microdose, Sema injection & oral, Tirz injection & oral, GLP-Squared
- Provider-managed dose titration with same-day prescription review
- No membership fees, no per-dose markups, no surprise charges
Personalized routing tool launches with our telehealth platform.
— AI Summary
What weight management at PlexusDx looks like, in 60 seconds.
PlexusDx offers six prescription weight loss protocols across four mechanism categories — GLP-1 injectable, GLP-1 oral, microdose, and dual-compound — with monthly prices ranging from $129 to $509. Every dose level for every compound is published on its product page before you enroll.
Every prescription is written by a licensed provider in your state, with telehealth coverage in all 50 states and no membership fees stacked on top of medication — so the protocol works for your body, your goals, and how you want to feel about your progress.
The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential GLP-1 response — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.
— What weight management at PlexusDx is
Prescription weight management, built around your biology.
PlexusDx weight management is a medically-supervised category — six prescription protocols across four mechanism classes (GLP-1 injectable, GLP-1 oral, microdose, dual-compound), prescribed by licensed providers in all 50 states and shipped monthly from a 503A pharmacy partner.
Three things define the category at PlexusDx — and together they're what makes the protocol something you can build a year around, not a 30-day stunt.
Pillar 01
Real prescriptions
Every protocol is reviewed and prescribed by a licensed provider in your state. No chatbot intake, no AI rx, no template-driven script. Clinical decisions stay with clinicians.
Pillar 02
Real medication
Compounded at a 503A state-licensed pharmacy partner, prepared individually for your prescription, and shipped monthly to your door. No marketplace, no third-party reseller, no surprise substitutions.
Pillar 03
Real personalization
The optional Precision Peptide Genetic Test analyzes 34 weight-management insights including GIPR rs1800437, so the protocol works for your body, your goals, and how you want to feel about your progress.
Category at a glance
6 protocols
Microdose, Sema injection & oral, Tirz injection & oral, GLP-Squared
Mechanism classes
4 mechanisms
GLP-1 injectable, GLP-1 oral, microdose, dual-compound
Coverage
All 50 states
Async telehealth, no clinic visit required
— Start here
How weight management care works at PlexusDx.
Foundational reading — six pillars before you commit to a protocol.
Pillar 01
What is genetic peptide testing?
The 14 pathways, 49 peptides, 150+ insights explained.
Read article →
Pillar 02
How AI reads your DNA for peptide protocols.
Inside the engine that turns SNPs into pathway insights.
Read article →
Pillar 03
The precision health stack, explained.
DNA + blood + supervised protocols — how the layers fit.
Read article →
Pillar 04
Test before you invest in a peptide protocol.
Why $99 of DNA may save you a year of trial-and-error.
Read article →
Pillar 05
How to read your peptide genetic test results.
A field guide to your dashboard, in plain English.
Read article →
Pillar 06
Genetics as a guide, not a guarantee.
What DNA testing can — and can't — tell you about peptides.
Read article →
— Six prescription protocols
Choose the protocol that fits your provider's plan.
Six options across four mechanism classes — your provider matches the protocol to your clinical profile.
Microdose GLP-1
Flat-priced provider-determined dose. Four variants — provider selects.
View protocol →
Semaglutide Injection
Weekly subcutaneous. The most-prescribed GLP-1 in U.S. telehealth.
View protocol →
Semaglutide Oral
Daily ODT. For patients who prefer no needles or rotating sites.
View protocol →
Tirzepatide Injection
Weekly dual-receptor agonist. Higher trial-data weight loss than single-receptor agonists.
View protocol →
Tirzepatide Oral
Daily ODT for the dual-receptor mechanism. Premium provider-routed.
View protocol →
PlexusDx exclusiveGLP-Squared
Semaglutide + Tirzepatide combined into a single weekly injection. PlexusDx exclusive formulation.
View protocol →
— What makes PlexusDx different
Your protocol, refined around your DNA.
PlexusDx analyzes 14 peptide-related pathways across 49 peptides. Two ways to bring genetics into your protocol — one for new customers, one for everyone already on file.
New customer path
Discover your weight management genetic profile.
Order the Precision Peptide Genetic Test — at-home cheek swab, CLIA-certified lab analysis, and a personalized 34-insight weight management report including GIPR rs1800437.
34
Weight management insights
across 14 pathways
Existing customer path
Add the Peptide Pathways Report.
Already have your DNA on file? Buy any additional pathway report for $29.99 — activates immediately in your Results Portal, no re-test needed.
$29.99
Per pathway report
activates immediately
— Injection vs oral
Injection or oral. Your provider routes you to the right one.
Same compounds. Same mechanism. Two ways to take them. The right format depends on dose tolerance, lifestyle, and how you want to take medicine — not which one is “better.”
Weekly injection
Higher dose ceiling, weekly cadence.
Dose range
Higher dose ceiling for longer titration runways. Provider may continue titrating beyond the standard oral plateau.
Lifestyle fit
For people comfortable with a self-administered shot once a week — set a recurring time and forget it.
Available compounds
Semaglutide injection, Tirzepatide injection, GLP-Squared.
Daily oral ODT
No needle, daily routine.
Dose range
Modest titration ladder using an oral-bioavailable compounded formulation. Lower ceiling than injection.
Lifestyle fit
For people who prefer no needles, no rotating sites, no shot anxiety, or a daily-routine medicine.
Available compounds
Semaglutide oral, Tirzepatide oral.
The decision
Your provider routes you based on dose tolerance, lifestyle, and clinical profile. Both deliver real GLP-1 mechanism.
Microdose GLP-1 spans both formats; GLP-Squared is injection-only. Final routing happens during your provider intake.
— Process
Four steps from start to shipped.
Most people are reviewed by a licensed provider the same business day they finish intake.
Choose your protocol.
NowBrowse six prescription protocols, or let your provider route you to the right one during intake.
Complete intake.
~60 secondsA few questions about your goals and health history. No medical records to upload, no forms to print.
Provider review.
Same business dayA licensed prescriber reviews your intake and confirms the protocol — or routes you to a better fit. Real medical authority, no AI prescriptions.
Medication ships.
3–5 business daysCompounded by a 503A pharmacy, shipped discreetly to your door. Future refills are reviewed by your provider before each ship.
— Pricing transparency
Every dose has a published price. What you see is what you pay.
Six prescription protocols across four mechanism classes. Each compound lists its starting dose-level price and its highest dose-level price. There are no platform fees, no membership stacks, and no per-dose surcharges layered on top — your monthly total is set by your compound tier, not by your dose.
| Compound | Form | Starting | Top |
|---|---|---|---|
| Microdose GLP-1 | Oral or injection | $129/mo flat | $129/mo flat |
| Semaglutide | Injection · weekly | $179/mo | $229/mo |
| Semaglutide | Oral · daily | $209/mo | $389/mo |
| Tirzepatide | Injection · weekly | $229/mo | $309/mo |
| Tirzepatide | Oral · daily | $229/mo | $509/mo |
| GLP-Squared | Oral · daily | $179/mo | $325/mo |
— Who weight management at PlexusDx is for
Designed for adults ready for medically-supervised weight management.
Every protocol is reviewed by a licensed provider in your state. Eligibility is set clinically, not by a chatbot. Here's who fits the program — and who doesn't.
— Who's a fit
You'd benefit from this protocol if…
-
You're an adult 18+ with a BMI of 27 or higher (or 25+ with a weight-related condition like prediabetes or hypertension).
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You want medical supervision and monthly monitoring, not a one-time prescription drop.
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You have no history of medullary thyroid carcinoma or MEN2 syndrome, and no active pancreatitis or gallbladder disease.
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You're committed to lifestyle support alongside medication — nutrition, movement, sleep.
— Who's not a fit
A different approach is better if…
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You're under 18. Our protocols are for adults only.
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You're pregnant, breastfeeding, or trying to conceive — GLP-1 medications are not appropriate during these life stages.
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You have a personal or family history of medullary thyroid carcinoma, MEN2, active pancreatitis, severe gastroparesis, or diabetic retinopathy.
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You're looking for a one-time prescription with no follow-up. We're built for the long game — monthly provider check-ins and titration, not a single fill-and-go transaction.
— What's included
One monthly price covers everything you need to start.
Every weight management protocol at PlexusDx ships with the same six service inclusions. No à la carte, no upsells at checkout, no platform fee layered on top of the price you saw on the previous section.
Real medical authority, no AI prescriptions
A board-licensed clinician reviews your intake and writes the script. No chatbot, no algorithmic approval.
Compounded medication shipped from a licensed 503A pharmacy
Your prescription is filled by a state-licensed compounding pharmacy and shipped directly to your door.
Ongoing clinical check-ins across your protocol cycle
Your provider monitors response, side effects, and progress — and adjusts your dose if needed within the same protocol.
Every refill is reviewed by your provider
Request your next month from your patient portal. Your provider re-authorizes each refill before the 503A pharmacy ships — no video call required.
Plain-label shipments. No branding on the outer box.
No sender name visible from the porch. No category language on the box. Patient privacy preserved at the curb.
Add the genetic test as a $99 add-on after your first month
150+ insights across 14 pathways. Optional, never required — your provider decides care without it.
All-inclusive monthly price
From $129/mo to $509/mo across six protocols.
No membership stack. No hidden fees. No surprise upgrades. The price you see on the previous pricing table is the price you pay.
— How we compare
Compare PlexusDx vs other weight management programs.
Four named programs. Same monthly comparison frame — what you actually pay, and what model the competitor uses to get there.
Why start here
Real medical authority, no AI prescriptions — and the only program that pairs every protocol with optional genetic insight.
One monthly price covers prescriber, 503A pharmacy, ongoing provider review, and refill fulfillment. No membership stack. No prepay lock-in.
Starts at
$129/mo
All-inclusive
Hims
Sema injection · $99/mo only with $495 upfront 5-month prepay
How we compare
PlexusDx bills monthly; Hims requires $495 upfront for the $99/mo rate.
Henry Meds
Sema injection · $297/mo flat all-inclusive
How we compare
PlexusDx is $118/mo less than Henry Meds at the starting Sema dose level — that's $1,416/yr.
Noom
App-based microdose GLP-1 · ~$99/mo
How we compare
PlexusDx Microdose is provider-prescribed with a clinical protocol; Noom is app-based, no clinical protocol, no genetics.
Calibrate
Membership $1,649/yr · medication billed separately
How we compare
PlexusDx includes prescriber + pharmacy + medication in one monthly price; Calibrate charges $1,649/yr membership before medication cost.
— The library
Read deeper before you start.
Three curated tracks. Five articles each. Choose the cluster that fits your question and read at your own pace before you talk to a provider.
Wm-specific
Weight management × your genetics.
Five reads on how DNA shapes the way GLP-1, dual-agonist, and growth-hormone-axis compounds work in your body.
Cross-family
Where weight management touches the rest of your health.
Five bridges into hormone, longevity, and muscle territory — because weight management rarely sits on its own.
If you’re considering hormone optimization too: men’s hormone genetic testing
If HRT is on your radar: women’s hormone genetic testing
If you’re thinking long-term: longevity and aging genetic testing
If you want to preserve muscle while losing weight: muscle growth genetic testing
If your weight is tied to growth hormone: IGF1 and the GH axis
Peptide pathways
The pathway library — five most-cited weight management reads.
The most-extracted articles from the Peptide Pathways library, drawn from the 34 weight management pathway posts.
— Frequently asked
Answers before you start.
Twenty-seven questions covering protocol mechanics, pricing, providers, refills, the optional genetic test, safety, and how weight management combines with other family protocols.
About the protocol
What the protocol is and how PlexusDx differs.
The medically supervised, all-inclusive monthly subscription model — and what makes it different from competing telehealth programs.
What is a PlexusDx weight management protocol?
A PlexusDx weight management protocol is a medically supervised, all-inclusive monthly subscription that includes a licensed prescriber consultation, your medication compounded by a 503A pharmacy, ongoing provider monitoring, and provider-reviewed refills. Six protocol options are available across GLP-1 single-agonist, dual-agonist, microdose, oral, and injection routes — covering Microdose GLP-1, Semaglutide Injection, Semaglutide Oral, Tirzepatide Injection, Tirzepatide Oral, and GLP-Squared.
How is PlexusDx different from Hims, Henry Meds, or Calibrate?
PlexusDx pairs every protocol with optional genetic insight from the Precision Peptide Genetic Test, bills monthly with no membership stack or upfront prepay commitment, and uses real medical authority — licensed prescribers, not AI prescriptions. Hims requires a $495 upfront 5-month commitment for the $99/mo rate, Calibrate charges $1,649/yr membership before medication cost, and Noom’s microdose program is app-based with no clinical protocol or genetics.
Is this a real medical protocol or just an online prescription service?
Every PlexusDx weight management protocol is a real, individualized medical protocol. A licensed prescriber reviews your intake, prescribes your medication, monitors your response, and re-authorizes every refill. The 503A pharmacy compounds your medication to that prescription. There is no AI prescribing, no auto-refill mechanism, and no protocol that ships without a provider in the loop on every step.
Are PlexusDx protocols available in all 50 states?
Yes. PlexusDx weight management protocols are available in all 50 US states through our CareValidate licensed provider network. Five states require a live telehealth video consultation rather than an asynchronous intake; the other 45 allow asynchronous intake. Your routing questionnaire identifies which path applies based on your state of residence, so you know what to expect before you start the medical intake.
Eligibility + getting started
Who qualifies and how to start.
Who PlexusDx weight management protocols are designed for, and the routing flow that gets you to the right protocol in about 60 seconds.
Am I eligible for a weight management protocol?
You’re eligible if you’re an adult 18 or older with a BMI of 27 or higher, or 25 or higher with a weight-related condition such as prediabetes or hypertension. You must have no history of medullary thyroid carcinoma, MEN2 syndrome, active pancreatitis, or severe gastroparesis. Pregnant, breastfeeding, or trying-to-conceive individuals are not eligible for GLP-1 protocols.
How do I get started?
Start with the Find My Protocol routing questionnaire — about 60 seconds — to identify which of the six weight management protocols fits your situation. From there you complete the CareValidate medical intake, a licensed prescriber reviews your case, and your medication ships from the 503A pharmacy within 3 to 5 business days of provider approval. Nothing is charged until your provider approves your prescription.
Do I need blood work to start a weight management protocol?
Blood work is not clinically required for GLP-1 weight management protocols at PlexusDx. Your provider may request labs based on your individual medical history, but the standard intake does not require a blood draw. This differs from our Men’s Hormone protocol, which does require a baseline TRT panel per AUA guidelines.
Pricing + billing
What you'll pay and what's included.
Compound-level pricing with full transparency. The price you see on the pricing table is the price you pay.
How much does a PlexusDx weight management protocol cost?
Weight management protocols start at $129/mo for Microdose GLP-1 — flat across all dose levels — and range to $509/mo for Tirzepatide Oral at the highest dose level. Semaglutide, Tirzepatide, and GLP-Squared protocols use compound-level pricing with per-dose-level transparency. Every dose has a published price. What you see on the pricing table is what you pay.
What’s included in the all-inclusive monthly price?
Your all-inclusive monthly price covers six things: licensed prescriber consultation, 503A pharmacy compounding, your medication, ongoing provider monitoring, provider-reviewed refills, and discreet shipping. The optional Precision Peptide Genetic Test is a $99 add-on available after your first month and is never required to start a protocol — bills monthly with no membership stack or hidden fees.
Are there any hidden fees, prepay commitments, or membership charges?
No. PlexusDx bills monthly with no membership fee, no annual prepay commitment, and no per-dose markup. The published price on the pricing table is your total monthly cost. Cancel anytime with no fees and no long-term contract — this is the sharpest competitive difference from Hims, Henry Meds, Noom, and Calibrate.
Medication + pharmacy
Where your medication comes from.
503A compounded medication, prepared by licensed pharmacies in response to your individual prescription.
Where does my medication come from?
Your medication is compounded by a licensed 503A pharmacy in response to your individual prescription. 503A pharmacies are state-board-regulated facilities that prepare patient-specific compounded medications under strict USP standards. This differs from FDA-branded retail medication — the 503A model gives PlexusDx pricing flexibility and dose-level customization that branded products do not allow.
Is compounded GLP-1 medication safe?
Compounded GLP-1 medication prepared by a licensed 503A pharmacy is held to USP compounding standards and is prescribed by your licensed provider for your individual case. Side effect profiles are similar to FDA-branded products. Your provider monitors your response monthly and adjusts your protocol based on tolerance and outcomes. Discuss any specific safety questions with your provider during intake.
How is my medication shipped?
Medication ships discreetly via temperature-controlled carrier, typically within 3 to 5 business days of your provider approving your prescription. Tracking is provided through your patient portal. Initial shipments include all supplies needed to begin — vials or oral tablets, syringes if applicable, and dosing instructions reviewed by your provider before the package leaves the 503A pharmacy.
Provider care
How provider care works on every protocol.
Licensed prescribers, monthly review, and provider-reviewed refills — real medical authority, no AI prescriptions.
Will I work with a real licensed provider?
Yes. Every PlexusDx weight management protocol is prescribed and monitored by a licensed provider in the CareValidate network — real medical authority, not AI prescriptions. Your provider reviews your intake, writes your prescription, monitors your response month over month, and re-authorizes every refill before the 503A pharmacy ships your medication.
How often will I communicate with my provider?
Your provider reviews your case at intake, every refill, and any time you request a check-in or report a concern through your patient portal. Standard cadence is monthly — your provider re-authorizes each refill based on your reported response, side effects, and progress. Additional check-ins are available at no extra cost during your active protocol.
Can I request a dose adjustment from my provider?
Yes. Dose titration is part of standard protocol management. Request a dose change through your patient portal — your provider reviews the request and titrates within the compound. If your provider determines a different compound is the better fit, they can switch you between compounds; your monthly billing updates to the new compound’s tier at that point.
Refills + ongoing protocol
How ongoing care continues month over month.
Provider-reviewed refills, compound switching, and what happens if you miss a month.
How do refills work?
Future refills are reviewed by your provider before each ship. Request your next month from your patient portal — your provider re-authorizes the refill based on your reported response and any side effect notes, then the 503A pharmacy ships. There is no auto-refill mechanism. Provider-reviewed refills are a deliberate part of the CareValidate protocol architecture, not a friction point.
What happens if I miss a refill?
Missing a refill request pauses your protocol — nothing ships until you request the next month and your provider re-authorizes. Your account stays active and you can resume anytime. If a longer gap occurs, your provider may want to reassess your protocol before resuming, especially for protocols with titrating dose levels.
Can I switch compounds without starting a new protocol?
Yes. If your provider determines a different compound is the better fit — for example, switching from Semaglutide to Tirzepatide, or stepping down to Microdose GLP-1 — you stay in your active protocol and your monthly billing updates to the new compound’s tier. No new intake required, no enrollment fees.
Genetic test add-on
The optional Precision Peptide Genetic Test.
An optional $99 add-on after your first month — never required to start a protocol.
What is the Precision Peptide Genetic Test?
The Precision Peptide Genetic Test analyzes how your genes influence weight management pathways and other peptide-related biological pathways. The panel covers 14 pathways, 49 peptides, and 150+ genetic insights — including 34 weight management pathway insights specifically. It does not recommend, prescribe, or determine which peptides you should use; consult a qualified healthcare provider before beginning any peptide protocol.
Do I need the genetic test to start a weight management protocol?
No. The Precision Peptide Genetic Test is an optional $99 add-on available after your first month of an active protocol. You can start any of the six weight management protocols without the test. If you do add the test later, the genetic insights are delivered through your Results Portal alongside your protocol care.
Side effects + safety
Side effects, contraindications, and emergencies.
Common side effects, conditions that disqualify, and what to do if something serious comes up.
What are the most common side effects?
Common GLP-1 side effects include nausea, mild gastrointestinal discomfort, decreased appetite, fatigue during dose escalation, and occasional injection-site reactions for injectable protocols. Most side effects are mild and improve over the first weeks as your body adjusts. Severe or persistent symptoms should be reported to your provider through the patient portal — your provider can adjust your dose or switch your compound if needed.
Are there conditions that disqualify me from a weight management protocol?
Yes. GLP-1 protocols are not appropriate if you have a personal or family history of medullary thyroid carcinoma, MEN2 syndrome, active pancreatitis, severe gastroparesis, or diabetic retinopathy. Pregnant, breastfeeding, or trying-to-conceive individuals are also not eligible. Your provider reviews your full medical history at intake and will flag any contraindications before prescribing.
What if I have a serious side effect?
Report any serious side effect to your provider immediately through the patient portal, which is monitored throughout business hours. For medical emergencies, call 911 or go to your nearest emergency department first, then notify your provider. Your provider can pause, adjust, or discontinue your protocol based on your report and recommend the appropriate next step for your care.
Cancel + change protocol
Cancelling, pausing, and changing your protocol.
Cancel anytime, pause anytime, and switch compounds without starting over.
How do I cancel my protocol?
Cancel anytime from your patient portal — no fees, no long-term contract, no phone calls required. Cancellation takes effect immediately and stops all future provider review and shipments. You retain access to your patient portal records and any unused medication you’ve already received. Re-enrollment is available anytime if you decide to resume later.
Can I pause my protocol instead of cancelling?
Yes. Skip a refill request to pause your protocol — your account stays active and you can resume anytime by requesting your next refill from your portal, which your provider then reviews. For longer pauses, your provider may want to reassess your protocol before resuming, especially at higher titrated dose levels where step-up pacing matters for tolerance.
Cross-protocol stacking
Combining weight management with other family protocols.
When weight management combines with men's hormone, women's hormone, or longevity protocols.
Can I stack a weight management protocol with a hormone or longevity protocol?
Stacking depends on your individual case and which protocols are involved. Some combinations — for example, weight management plus women’s hormone protocols during perimenopause, or weight management plus men’s TRT — are clinically appropriate when your provider reviews both intakes together. Discuss any stacking interest with your provider during intake; they will determine the right sequence and combination for your situation.
— Ready when you are
All-inclusive · all 50 states
Real medical authority, no AI prescriptions. Six protocols, your choice.
Bills monthly · Cancel anytime
No membership stack. No upfront prepay commitment. Published prices on every dose level.
Health markers you can measure. Mirror outcomes you can see.
Both belong in the same protocol — backed by licensed prescribers and a 503A pharmacy.
Important information
Compounded medications are not approved by the FDA or reviewed for quality, safety, or efficacy.
Novo Nordisk, Inc. is the only United States company with FDA-approved products containing semaglutide, identified under the trade names Rybelsus®, Ozempic®, and Wegovy®.
Lilly USA LLC is the only United States company with FDA-approved products containing tirzepatide, identified under the trade names Zepbound® and Mounjaro®.
The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.